Factor |
Source in the
human body |
Primary Activity |
Comments |
PDGF |
platelets, endothelial
cells |
promotes proliferation
of connective tissue, glial and smooth muscle cells |
two different protein
chains form 3 distinct dimer forms; AA, AB and BB |
EGF |
submaxillary gland,
Brunners gland |
promotes proliferation
of mesenchymal, glial and epithelial cells |
|
TGF-a |
common in transformed
cells |
may be important
for normal wound healing |
related to EGF |
FGF |
wide range of cells;
protein is associated with the ECM |
promotes proliferation
of many cells; inhibits some stem cells; induces mesoderm
to form in early embryos |
at least 19 family
members, 4 distinct receptors |
TGF-b |
activated TH1
cells (T-helper) and natural killer (NK) cells |
anti-inflammatory
(suppresses cytokine production and class II MHC expression),
promotes wound healing, inhibits |
at least 100 different
family members |
